Synthesis of 11-cis-retinol and Its Incorporation into FeO Nano Particles
Abstract
The light sensitivity of 11-cis-retinoid makes it an ideal chromophore. Since retinoids are not synthesized in human, eyes have evolved a unique recycling mechanism for generating 11-cis-retinal at retinal pigmented epithelium (RPE). The goals of my research are to synthesize 11-cis-retinol, attach it to phosphoric acid derivatives, and bind this complex to FeO Nanoparticles directly in order to deliver 11-cis-retinol as a therapeutic for eye diseases like macular degeneration and Leber's Congenital Amaurosis (LCA).
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